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Contribution of Intrinsic Lactate to Maintenance of Seizure Activity in Neocortical Slices from Patients with Temporal Lobe Epilepsy and in Rat Entorhinal Cortex

Neuronal lactate uptake supports energy metabolism associated with synaptic signaling and recovery of extracellular ion gradients following neuronal activation. Altered expression of the monocarboxylate transporters (MCT) in temporal lobe epilepsy (TLE) hampers lactate removal into the bloodstream....

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Angamo, Eskedar Ayele, Haq, Rizwan ul, Rösner, Jörg, Gabriel, Siegrun, Gerevich, Zoltán, Heinemann, Uwe, Kovács, Richard
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618484/
https://ncbi.nlm.nih.gov/pubmed/28832554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18091835
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