Contribution of Intrinsic Lactate to Maintenance of Seizure Activity in Neocortical Slices from Patients with Temporal Lobe Epilepsy and in Rat Entorhinal Cortex

Neuronal lactate uptake supports energy metabolism associated with synaptic signaling and recovery of extracellular ion gradients following neuronal activation. Altered expression of the monocarboxylate transporters (MCT) in temporal lobe epilepsy (TLE) hampers lactate removal into the bloodstream....

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Publicado en:Int J Mol Sci
Autores principales: Angamo, Eskedar Ayele, Haq, Rizwan ul, Rösner, Jörg, Gabriel, Siegrun, Gerevich, Zoltán, Heinemann, Uwe, Kovács, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618484/
https://ncbi.nlm.nih.gov/pubmed/28832554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18091835
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