Contribution of Intrinsic Lactate to Maintenance of Seizure Activity in Neocortical Slices from Patients with Temporal Lobe Epilepsy and in Rat Entorhinal Cortex

Neuronal lactate uptake supports energy metabolism associated with synaptic signaling and recovery of extracellular ion gradients following neuronal activation. Altered expression of the monocarboxylate transporters (MCT) in temporal lobe epilepsy (TLE) hampers lactate removal into the bloodstream....

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Angamo, Eskedar Ayele, Haq, Rizwan ul, Rösner, Jörg, Gabriel, Siegrun, Gerevich, Zoltán, Heinemann, Uwe, Kovács, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618484/
https://ncbi.nlm.nih.gov/pubmed/28832554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18091835
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