Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism

Skeletal muscle is a key organ in energy homeostasis owing to its high requirement for nutrients. Heterotrimeric G proteins converge signals from cell-surface receptors to potentiate or blunt responses against environmental changes. Here, we show that muscle-specific ablation of Gα13 in mice promote...

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Pubblicato in:J Clin Invest
Autori principali: Koo, Ja Hyun, Kim, Tae Hyun, Park, Shi-Young, Joo, Min Sung, Han, Chang Yeob, Choi, Cheol Soo, Kim, Sang Geon
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617657/
https://ncbi.nlm.nih.gov/pubmed/28920922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92067
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