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A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca(2+) cooperativity of vesicle fusion
The synaptic vesicle Ca(2+) sensor Synaptotagmin binds Ca(2+) through its two C2 domains to trigger membrane interactions. Beyond membrane insertion by the C2 domains, other requirements for Synaptotagmin activity are still being elucidated. To identify key residues within Synaptotagmin required for...
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| Опубликовано в: : | eLife |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
eLife Sciences Publications, Ltd
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5617632/ https://ncbi.nlm.nih.gov/pubmed/28895532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28409 |
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