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A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca(2+) cooperativity of vesicle fusion

The synaptic vesicle Ca(2+) sensor Synaptotagmin binds Ca(2+) through its two C2 domains to trigger membrane interactions. Beyond membrane insertion by the C2 domains, other requirements for Synaptotagmin activity are still being elucidated. To identify key residues within Synaptotagmin required for...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Guan, Zhuo, Bykhovskaia, Maria, Jorquera, Ramon A, Sutton, Roger Bryan, Akbergenova, Yulia, Littleton, J Troy
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617632/
https://ncbi.nlm.nih.gov/pubmed/28895532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28409
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