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A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca(2+) cooperativity of vesicle fusion

The synaptic vesicle Ca(2+) sensor Synaptotagmin binds Ca(2+) through its two C2 domains to trigger membrane interactions. Beyond membrane insertion by the C2 domains, other requirements for Synaptotagmin activity are still being elucidated. To identify key residues within Synaptotagmin required for...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Guan, Zhuo, Bykhovskaia, Maria, Jorquera, Ramon A, Sutton, Roger Bryan, Akbergenova, Yulia, Littleton, J Troy
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617632/
https://ncbi.nlm.nih.gov/pubmed/28895532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28409
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