Expression of LAG-3 defines exhaustion of intratumoral PD-1(+) T cells and correlates with poor outcome in follicular lymphoma

Exhausted T-cells in follicular lymphoma (FL) typically express PD-1, but expression of PD-1 is not limited to exhausted cells. Although expected to be functionally suppressed, we found that the population of intratumoral PD-1(+) T cells were predominantly responsible for production of cytokines and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yang, Zhi-Zhang, Kim, Hyo Jin, Villasboas, Jose C., Chen, Ya-Ping, Price-Troska, Tammy, Jalali, Shahrzad, Wilson, Mara, Novak, Anne J., Ansell, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617435/
https://ncbi.nlm.nih.gov/pubmed/28977875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18251
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