First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor

The polycomb repressive complex 2 (PRC2) histone methyltransferase plays a central role in epigenetic regulation in development and in cancer, and hence to interrogate its role in a specific developmental transition, methods are needed for disrupting function of the complex with high temporal and sp...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Moody, James D., Levy, Shiri, Mathieu, Julie, Xing, Yalan, Kim, Woojin, Dong, Cheng, Tempel, Wolfram, Robitaille, Aaron M., Dang, Luke T., Ferreccio, Amy, Detraux, Damien, Sidhu, Sonia, Zhu, Licheng, Carter, Lauren, Xu, Chao, Valensisi, Cristina, Wang, Yuliang, Hawkins, R. David, Min, Jinrong, Moon, Randall T., Orkin, Stuart H., Baker, David, Ruohola-Baker, Hannele
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2017
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617284/
https://ncbi.nlm.nih.gov/pubmed/28864533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706907114
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