First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor

The polycomb repressive complex 2 (PRC2) histone methyltransferase plays a central role in epigenetic regulation in development and in cancer, and hence to interrogate its role in a specific developmental transition, methods are needed for disrupting function of the complex with high temporal and sp...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Moody, James D., Levy, Shiri, Mathieu, Julie, Xing, Yalan, Kim, Woojin, Dong, Cheng, Tempel, Wolfram, Robitaille, Aaron M., Dang, Luke T., Ferreccio, Amy, Detraux, Damien, Sidhu, Sonia, Zhu, Licheng, Carter, Lauren, Xu, Chao, Valensisi, Cristina, Wang, Yuliang, Hawkins, R. David, Min, Jinrong, Moon, Randall T., Orkin, Stuart H., Baker, David, Ruohola-Baker, Hannele
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617284/
https://ncbi.nlm.nih.gov/pubmed/28864533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706907114
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