A20 Restrains Thymic Regulatory T Cell Development

Maintaining immune tolerance requires the production of Foxp3-expressing regulatory T (T(reg)) cells in the thymus. Activation of NF-κB transcription factors is critically required for T(reg) cell development, partly via initiating Foxp3 expression. NF-κB activation is controlled by a negative feedb...

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Udgivet i:J Immunol
Main Authors: Fischer, Julius Clemens, Otten, Vera, Kober, Maike, Drees, Christoph, Rosenbaum, Marc, Schmickl, Martina, Heidegger, Simon, Beyaert, Rudi, van Loo, Geert, Li, Xian Chang, Peschel, Christian, Schmidt-Supprian, Marc, Haas, Tobias, Spoerl, Silvia, Poeck, Hendrik
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617121/
https://ncbi.nlm.nih.gov/pubmed/28842469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1602102
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