Quantifiable predictive features define epitope specific T cell receptor repertoires

T cells are defined by a heterodimeric surface receptor (the T cell receptor or TCR) that mediates recognition of pathogen-associated epitopes via interactions with peptide-major histocompatibility complexes (pMHC). TCRs are generated by genomic rearrangements of the germline TCR locus, a process te...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Dash, Pradyot, Fiore-Gartland, Andrew J., Hertz, Tomer, Wang, George C., Sharma, Shalini, Souquette, Aisha, Crawford, Jeremy Chase, Clemens, E. Bridie, Nguyen, Thi H. O., Kedzierska, Katherine, La Gruta, Nicole L., Bradley, Philip, Thomas, Paul G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5616171/
https://ncbi.nlm.nih.gov/pubmed/28636592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22383
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