A proteomic atlas of insulin signalling reveals tissue‐specific mechanisms of longevity assurance

Lowered activity of the insulin/IGF signalling (IIS) network can ameliorate the effects of ageing in laboratory animals and, possibly, humans. Although transcriptome remodelling in long‐lived IIS mutants has been extensively documented, the causal mechanisms contributing to extended lifespan, partic...

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Publicat a:Mol Syst Biol
Autors principals: Tain, Luke S, Sehlke, Robert, Jain, Chirag, Chokkalingam, Manopriya, Nagaraj, Nagarjuna, Essers, Paul, Rassner, Mark, Grönke, Sebastian, Froelich, Jenny, Dieterich, Christoph, Mann, Matthias, Alic, Nazif, Beyer, Andreas, Partridge, Linda
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5615923/
https://ncbi.nlm.nih.gov/pubmed/28916541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20177663
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