MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity

MicroRNAs (miRNAs) that regulate the cytochrome P-450 isoforms involved in acetaminophen (APAP) toxicity were examined in HepaRG cells treated with APAP (20 mM). In-vitro studies found that APAP protein adducts were increased at 1 h, followed by ALT increases at 12 and 24 h. CYP1A2, CYP3A4 and CYP2E...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Gill, Pritmohinder, Bhattacharyya, Sudeepa, McCullough, Sandra, Letzig, Lynda, Mishra, Prasun J., Luo, Chunqiao, Dweep, Harsh, James, Laura
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614957/
https://ncbi.nlm.nih.gov/pubmed/28951593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11811-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items