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Coarse-grained Simulations of Conformational Changes in Multidrug Efflux Transporter AcrB

The multidrug resistance (MDR) system actively pumps the antibiotics out of cells causing serious health problems. During the pumping, AcrB (one of the key MDR components), undergoes a series of large-scale and proton-motive conformational changes. Capturing the conformational changes through all-at...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Biosyst
Main Authors: Jewel, Yead, Liu, Jin, Dutta, Prashanta
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614849/
https://ncbi.nlm.nih.gov/pubmed/28770910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7mb00276a
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