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Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB
The tripartite efflux pump assembly AcrAB-TolC is the major multidrug resistance transporter in E. coli. The inner membrane transporter AcrB is a homotrimer, energized by the proton movement down the transmembrane electrochemical gradient. The asymmetric crystal structures of AcrB with three monomer...
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| Publicado no: | Front Microbiol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394701/ https://ncbi.nlm.nih.gov/pubmed/25918513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2015.00302 |
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