AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

A causative understanding of genetic factors that regulate glioblastoma (GBM) pathogenesis is of central importance. Here, we developed an adeno-associated virus (AAV)-mediated autochthonous CRISPR screen in GBM. Stereotaxic delivery of an AAV library targeting genes commonly mutated in human cancer...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Chow, Ryan D., Guzman, Christopher D., Wang, Guangchuan, Schmidt, Florian, Youngblood, Mark W., Ye, Lupeng, Errami, Youssef, Dong, Matthew B., Martinez, Michael A., Zhang, Sensen, Renauer, Paul, Bilguvar, Kaya, Gunel, Murat, Sharp, Phillip A., Zhang, Feng, Platt, Randall J., Chen, Sidi
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614841/
https://ncbi.nlm.nih.gov/pubmed/28805815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4620
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