rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model

Recombinant adeno-associated virus (rAAV) vectors are clinically adapted vectors to durably treat human osteoarthritis (OA). Controlled delivery of rAAV vectors via polymeric micelles was reported to enhance the temporal and spatial presentation of the vectors into their targets. Here, we tested the...

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Dettagli Bibliografici
Pubblicato in:Int J Nanomedicine
Autori principali: Rey-Rico, Ana, Venkatesan, Jagadeesh K, Schmitt, Gertrud, Concheiro, Angel, Madry, Henning, Alvarez-Lorenzo, Carmen, Cucchiarini, Magali
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2017
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614797/
https://ncbi.nlm.nih.gov/pubmed/29033566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S144579
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