rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model

Recombinant adeno-associated virus (rAAV) vectors are clinically adapted vectors to durably treat human osteoarthritis (OA). Controlled delivery of rAAV vectors via polymeric micelles was reported to enhance the temporal and spatial presentation of the vectors into their targets. Here, we tested the...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Int J Nanomedicine
Auteurs principaux: Rey-Rico, Ana, Venkatesan, Jagadeesh K, Schmitt, Gertrud, Concheiro, Angel, Madry, Henning, Alvarez-Lorenzo, Carmen, Cucchiarini, Magali
Format: Artigo
Langue:Inglês
Publié: Dove Medical Press 2017
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614797/
https://ncbi.nlm.nih.gov/pubmed/29033566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S144579
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires