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Computational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26

Due to the increasing prevalence of diabetes, finding therapeutic analogues for insulin has become an urgent issue. While many experimental studies have been performed towards this end, they have limited scope to examine all aspects of the effect of a mutation. Computational studies can help to over...

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Pubblicato in:Biochem Biophys Rep
Autori principali: Papaioannou, Anastasios, Kuyucak, Serdar, Kuncic, Zdenka
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614686/
https://ncbi.nlm.nih.gov/pubmed/28955783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2017.04.006
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