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Elucidating the Activation Mechanism of the Insulin-Family Proteins with Molecular Dynamics Simulations
The insulin-family proteins bind to their own receptors, but insulin-like growth factor II (IGF-II) can also bind to the A isoform of the insulin receptor (IR-A), activating unique and alternative signaling pathways from those of insulin. Although extensive studies of insulin have revealed that its...
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| Опубликовано в: : | PLoS One |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4993506/ https://ncbi.nlm.nih.gov/pubmed/27548502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161459 |
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