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Molecular Dynamics Simulations of Insulin: Elucidating the Conformational Changes that Enable Its Binding
A sequence of complex conformational changes is required for insulin to bind to the insulin receptor. Recent experimental evidence points to the B chain C-terminal (BC-CT) as the location of these changes in insulin. Here, we present molecular dynamics simulations of insulin that reveal new insights...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4668001/ https://ncbi.nlm.nih.gov/pubmed/26629689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144058 |
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