nsPEF-induced PIP(2) depletion, PLC activity and actin cytoskeletal cortex remodeling are responsible for post-exposure cellular swelling and blebbing

Cell swelling and blebbing has been commonly observed following nanosecond pulsed electric field (nsPEF) exposure. The hypothesized origin of these effects is nanoporation of the plasma membrane (PM) followed by transmembrane diffusion of extracellular fluid and disassembly of cortical actin structu...

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發表在:Biochem Biophys Rep
Main Authors: Tolstykh, Gleb P., Thompson, Gary L., Beier, Hope T., Steelman, Zachary A., Ibey, Bennett L.
格式: Artigo
語言:Inglês
出版: Elsevier 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614542/
https://ncbi.nlm.nih.gov/pubmed/28955986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2016.11.005
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