Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

While it is recognized that aquaporin-4 (AQP4)-specific T cells and antibodies participate in the pathogenesis of neuromyelitis optica (NMO), a human central nervous system (CNS) autoimmune demyelinating disease, creation of an AQP4-targeted model with both clinical and histologic manifestations of...

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Udgivet i:J Vis Exp
Main Authors: Sagan, Sharon A., Cruz-Herranz, Andrés, Spencer, Collin M., Ho, Peggy P., Steinman, Lawrence, Green, Ari J., Sobel, Raymond A., Zamvil, Scott S.
Format: Artigo
Sprog:Inglês
Udgivet: MyJove Corporation 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614352/
https://ncbi.nlm.nih.gov/pubmed/28872108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/56185
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