Deletion of the L-Lactate Dehydrogenase Gene ldh in Streptococcus pyogenes Leads to a Loss of SpeB Activity and a Hypovirulent Phenotype

Streptococcus pyogenes uses lactic acid fermentation for the generation of ATP. Here, we analyzed the impact of a deletion of the L-lactate dehydrogenase gene ldh on the virulence of S. pyogenes M49. While the ldh deletion does not cause a general growth deficiency in laboratory media, the growth in...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Oehmcke-Hecht, Sonja, Nass, Leif E., Wichura, Jan B., Mikkat, Stefan, Kreikemeyer, Bernd, Fiedler, Tomas
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5613712/
https://ncbi.nlm.nih.gov/pubmed/28983299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.01841
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