Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers

More than 20 genetic loci have been associated with risk for Alzheimer’s disease (AD), but reported genome-wide significant loci do not account for all the estimated heritability and provide little information about underlying biological mechanisms. Genetic studies using intermediate quantitative tr...

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Wydane w:Acta Neuropathol
Główni autorzy: Deming, Yuetiva, Li, Zeran, Kapoor, Manav, Harari, Oscar, Del-Aguila, Jorge L., Black, Kathleen, Carrell, David, Cai, Yefei, Fernandez, Maria Victoria, Budde, John, Ma, Shengmei, Saef, Benjamin, Howells, Bill, Huang, Kuanlin, Bertelsen, Sarah, Fagan, Anne M., Holtzman, David M., Morris, John C., Kim, Sungeun, Saykin, Andrew J., De Jager, Philip L., Albert, Marilyn, Moghekar, Abhay, O’Brien, Richard, Riemenschneider, Matthias, Petersen, Ronald C., Blennow, Kaj, Zetterberg, Henrik, Minthon, Lennart, Van Deerlin, Vivianna M., Lee, Virginia Man-Yee, Shaw, Leslie M., Trojanowski, John Q., Schellenberg, Gerard, Haines, Jonathan L., Mayeux, Richard, Pericak-Vance, Margaret A., Farrer, Lindsay A., Peskind, Elaine R., Li, Ge, Di Narzo, Antonio F., Kauwe, John S. K., Goate, Alison M., Cruchaga, Carlos
Format: Artigo
Język:Inglês
Wydane: 2017
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5613285/
https://ncbi.nlm.nih.gov/pubmed/28247064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1685-y
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