An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAF(V600E) inhibitor-resistant metastatic melanoma cells

The ingrained capacity of melanoma cells to rapidly evolve toward an aggressive phenotype is manifested by their increased ability to develop drug-resistance, evident in the case of vemurafenib, a therapeutic-agent targeting BRAF(V600E). Previous studies indicated a tight correlation between heighte...

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Bibliographic Details
Published in:Autophagy
Main Authors: Martin, Shaun, Dudek-Peric, Aleksandra M., Garg, Abhishek D., Roose, Heleen, Demirsoy, Seyma, Van Eygen, Sofie, Mertens, Freya, Vangheluwe, Peter, Vankelecom, Hugo, Agostinis, Patrizia
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
Subjects:
Basic Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612289/
https://ncbi.nlm.nih.gov/pubmed/28722539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1332550
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