Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors

Sonic hedgehog (SHH) is an essential morphogenetic signal that dictates cell fate decisions in several developing organs in mammals. In vitro data suggest that SHH is required to specify LHX3(+)/LHX4(+) Rathke's pouch (RP) progenitor identity. However, in vivo studies have failed to reveal such...

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Détails bibliographiques
Publié dans:Development
Auteurs principaux: Carreno, Gabriela, Apps, John R., Lodge, Emily J., Panousopoulos, Leonidas, Haston, Scott, Gonzalez-Meljem, Jose Mario, Hahn, Heidi, Andoniadou, Cynthia L., Martinez-Barbera, Juan Pedro
Format: Artigo
Langue:Inglês
Publié: The Company of Biologists Ltd 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612255/
https://ncbi.nlm.nih.gov/pubmed/28807898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.153387
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