Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors

Sonic hedgehog (SHH) is an essential morphogenetic signal that dictates cell fate decisions in several developing organs in mammals. In vitro data suggest that SHH is required to specify LHX3(+)/LHX4(+) Rathke's pouch (RP) progenitor identity. However, in vivo studies have failed to reveal such...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Carreno, Gabriela, Apps, John R., Lodge, Emily J., Panousopoulos, Leonidas, Haston, Scott, Gonzalez-Meljem, Jose Mario, Hahn, Heidi, Andoniadou, Cynthia L., Martinez-Barbera, Juan Pedro
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612255/
https://ncbi.nlm.nih.gov/pubmed/28807898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.153387
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