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The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development
IRE1 mediates the unfolded protein response (UPR) in part by regulating XBP1 mRNA splicing in response to endoplasmic reticulum (ER) stress. In cultured metazoan cells, IRE1 also exhibits XBP1-independent biochemical activities. IRE1 and XBP1 are developmentally essential genes in Drosophila and mam...
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| Publié dans: | J Cell Sci |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Company of Biologists Ltd
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5612175/ https://ncbi.nlm.nih.gov/pubmed/28775151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.203612 |
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