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A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity

Molecular agents that specifically bind and neutralize misfolded and toxic superoxide dismutase 1 (SOD1) mutant proteins may find application in attenuating the disease progression of familial amyotrophic lateral sclerosis. However, high structural similarities between the wild-type and mutant SOD1...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Banerjee, Victor, Oren, Ofek, Ben-Zeev, Efrat, Taube, Ran, Engel, Stanislav, Papo, Niv
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612109/
https://ncbi.nlm.nih.gov/pubmed/28768772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.789610
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