CD28 Blockade Ex Vivo Induces Alloantigen-Specific Immune Tolerance but Preserves T-Cell Pathogen Reactivity

Donor T-cells contribute to reconstitution of protective immunity after allogeneic hematopoietic stem cell transplantation (HSCT) but must acquire specific tolerance against recipient alloantigens to avoid life-threatening graft-versus-host disease (GvHD). Systemic immunosuppressive drugs may abroga...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Dillinger, Barbara, Ahmadi-Erber, Sarah, Soukup, Klara, Halfmann, Angela, Schrom, Silke, Vanhove, Bernard, Steinberger, Peter, Geyeregger, Rene, Ladisch, Stephan, Dohnal, Alexander Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5611377/
https://ncbi.nlm.nih.gov/pubmed/28979262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01152
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