The Fluorocycline TP-271 Is Efficacious in Models of Aerosolized Bacillus anthracis Infection in BALB/c Mice and Cynomolgus Macaques

The fluorocycline TP-271 was evaluated in mouse and nonhuman primate (NHP) models of inhalational anthrax. BALB/c mice were exposed by nose-only aerosol to Bacillus anthracis Ames spores at a level of 18 to 88 lethal doses sufficient to kill 50% of exposed individuals (LD(50)). When 21 days of once-...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Grossman, Trudy H., Anderson, Michael S., Drabek, Lindsay, Gooldy, Melanie, Heine, Henry S., Henning, Lisa N., Lin, Winston, Newman, Joseph V., Nevarez, Rene, Siefkas-Patterson, Kaylyn, Radcliff, Anne K., Sutcliffe, Joyce A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610513/
https://ncbi.nlm.nih.gov/pubmed/28784679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01103-17
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