Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic

TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms, including tetracycline-specific efflux and ribosomal protection. The mechanism of action of TP-434 was assessed using both cell-based and in vitro assays. In E...

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Detalhes bibliográficos
Main Authors: Grossman, Trudy H., Starosta, Agata L., Fyfe, Corey, O'Brien, William, Rothstein, David M., Mikolajka, Aleksandra, Wilson, Daniel N., Sutcliffe, Joyce A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346605/
https://ncbi.nlm.nih.gov/pubmed/22354310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06187-11
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