GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response

Glycoprotein nonmetastatic melanoma protein B (GPNMB) has a neuroprotective effect against neuronal cell death caused by the accumulation of abnormal mutated proteins. It is known that the accumulation of pathological proteins induces endoplasmic-reticulum (ER) stress leading to cell damage. The aim...

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Publicado no:Sci Rep
Main Authors: Noda, Yasuhiro, Tsuruma, Kazuhiro, Takata, Masafumi, Ishisaka, Mitsue, Tanaka, Hirotaka, Nakano, Yusuke, Nagahara, Yuki, Shimazawa, Masamitsu, Hara, Hideaki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610265/
https://ncbi.nlm.nih.gov/pubmed/28939899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11828-3
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