A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates containing deletions in the 3′ untranslate...

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Udgivet i:Nat Commun
Main Authors: Shan, Chao, Muruato, Antonio E., Jagger, Brett W., Richner, Justin, Nunes, Bruno T. D., Medeiros, Daniele B. A., Xie, Xuping, Nunes, Jannyce G. C., Morabito, Kaitlyn M., Kong, Wing-Pui, Pierson, Theodore C., Barrett, Alan D., Weaver, Scott C., Rossi, Shannan L., Vasconcelos, Pedro F. C., Graham, Barney S., Diamond, Michael S., Shi, Pei-Yong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610254/
https://ncbi.nlm.nih.gov/pubmed/28939807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00737-8
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