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Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer’s Disease Pathogenesis
Presenilin 1 (PS1) is a catalytic component of the γ-secretase complex, responsible for the intramembraneous cleavage of more than 90 type I transmembrane proteins, including Alzheimer’s disease (AD)-related amyloid precursor protein (APP). The γ-secretase-mediated cleavage of the APP C-terminal mem...
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| Yayımlandı: | Mol Neurobiol |
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| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5610083/ https://ncbi.nlm.nih.gov/pubmed/28332150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-017-0487-5 |
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