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USP21 regulates Hippo pathway activity by mediating MARK protein turnover
The Hippo pathway, which acts to repress the activity of YAP and TAZ trancriptional co-activators, serve as a barrier for oncogenic transformation. Unlike other oncoproteins, YAP and TAZ are rarely activated by mutations or amplified in cancer. However, elevated YAP/TAZ activity is frequently observ...
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| Опубликовано в: : | Oncotarget |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Impact Journals LLC
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5609986/ https://ncbi.nlm.nih.gov/pubmed/28969054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19322 |
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