Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover

The Hippo pathway has been identified as a key barrier for tumorigenesis, acting through downregulation of YAP/TAZ activity. Elevated YAP/TAZ activity has been documented in many human cancers. Ubiquitylation has been shown to play a key role in regulating YAP/TAZ activity through downregulation of...

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Udgivet i:Cell Discov
Main Authors: Thanh Nguyen, Hung, Andrejeva, Diana, Gupta, Rajat, Choudhary, Chunaram, Hong, Xin, Eichhorn, Pieter J A, Loya, Anand C, Cohen, Stephen M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849470/
https://ncbi.nlm.nih.gov/pubmed/27462448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.1
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