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Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover
The Hippo pathway has been identified as a key barrier for tumorigenesis, acting through downregulation of YAP/TAZ activity. Elevated YAP/TAZ activity has been documented in many human cancers. Ubiquitylation has been shown to play a key role in regulating YAP/TAZ activity through downregulation of...
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| 出版年: | Cell Discov |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4849470/ https://ncbi.nlm.nih.gov/pubmed/27462448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.1 |
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