Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies

Paediatric sarcomas and brain tumours, remain cancers of significant unmet need, with a poor prognosis for patients with high risk disease or those who relapse, and significant morbidities from treatment for those that survive using standard treatment approaches. Novel treatment strategies, based on...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Vardon, Ashley, Dandapani, Madhumita, Cheng, Daryl, Cheng, Paul, De Santo, Carmela, Mussai, Francis
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609939/
https://ncbi.nlm.nih.gov/pubmed/28969007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18843
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