The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading

Cancer cells exhibit mitochondrial cholesterol (mt-cholesterol) accumulation, which contributes to cell death resistance by antagonizing mitochondrial outer membrane (MOM) permeabilization. Hepatocellular mt-cholesterol loading, however, promotes steatohepatitis, an advanced stage of chronic liver d...

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Publicat a:Redox Biol
Autors principals: Baulies, Anna, Montero, Joan, Matías, Nuria, Insausti, Naroa, Terrones, Oihana, Basañez, Gorka, Vallejo, Carmen, de La Rosa, Laura Conde, Martinez, Laura, Robles, David, Morales, Albert, Abian, Joaquin, Carrascal, Montserrat, Machida, Keigo, Kumar, Dinesh B.U., Tsukamoto, Hidekazu, Kaplowitz, Neil, Garcia-Ruiz, Carmen, Fernández-Checa, José C.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609874/
https://ncbi.nlm.nih.gov/pubmed/28942194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.08.022
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