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Photochemical Generation of Benzyl Cations That Selectively Cross-Link Guanine and Cytosine in DNA

UV irradiation of several aryl boronates efficiently produced bifunctional benzyl cations that selectively form guanine-cytosine cross-links in DNA. Photoinduced homolysis of the C–Br bond took place with the aryl boronate bromides 3a and 4a, generating free radicals that were oxidized to benzyl cat...

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Bibliografiske detaljer
Udgivet i:Org Lett
Main Authors: Wang, Yibin, Liu, Shuo, Lin, Zechao, Fan, Yukai, Wang, Yinsheng, Peng, Xiaohua
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609456/
https://ncbi.nlm.nih.gov/pubmed/27191599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b00755
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