Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung

Our aim was to investigate if deoxyribonuclease (DNase) 1 is a potential therapeutic agent to reduce pathogenic effects of cigarette smoke exposure in the lung. Cigarette smoke causes protease imbalance with excess production of proteases, which is a key process in the pathogenesis of emphysema. The...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: King, Paul T., Sharma, Roleen, O’Sullivan, Kim M., Callaghan, Judy, Dousha, Lovisa, Thomas, Belinda, Ruwanpura, Saleela, Lim, Steven, Farmer, Michael W., Jennings, Barton R., Finsterbusch, Michaela, Brooks, Gavin, Selemidis, Stavros, Anderson, Gary P., Holdsworth, Stephen R., Bardin, Philip G.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608940/
https://ncbi.nlm.nih.gov/pubmed/28935869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12474-5
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