Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung

Our aim was to investigate if deoxyribonuclease (DNase) 1 is a potential therapeutic agent to reduce pathogenic effects of cigarette smoke exposure in the lung. Cigarette smoke causes protease imbalance with excess production of proteases, which is a key process in the pathogenesis of emphysema. The...

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Udgivet i:Sci Rep
Main Authors: King, Paul T., Sharma, Roleen, O’Sullivan, Kim M., Callaghan, Judy, Dousha, Lovisa, Thomas, Belinda, Ruwanpura, Saleela, Lim, Steven, Farmer, Michael W., Jennings, Barton R., Finsterbusch, Michaela, Brooks, Gavin, Selemidis, Stavros, Anderson, Gary P., Holdsworth, Stephen R., Bardin, Philip G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608940/
https://ncbi.nlm.nih.gov/pubmed/28935869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12474-5
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