Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung

Our aim was to investigate if deoxyribonuclease (DNase) 1 is a potential therapeutic agent to reduce pathogenic effects of cigarette smoke exposure in the lung. Cigarette smoke causes protease imbalance with excess production of proteases, which is a key process in the pathogenesis of emphysema. The...

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Publicat a:Sci Rep
Autors principals: King, Paul T., Sharma, Roleen, O’Sullivan, Kim M., Callaghan, Judy, Dousha, Lovisa, Thomas, Belinda, Ruwanpura, Saleela, Lim, Steven, Farmer, Michael W., Jennings, Barton R., Finsterbusch, Michaela, Brooks, Gavin, Selemidis, Stavros, Anderson, Gary P., Holdsworth, Stephen R., Bardin, Philip G.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608940/
https://ncbi.nlm.nih.gov/pubmed/28935869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12474-5
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