Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung

Our aim was to investigate if deoxyribonuclease (DNase) 1 is a potential therapeutic agent to reduce pathogenic effects of cigarette smoke exposure in the lung. Cigarette smoke causes protease imbalance with excess production of proteases, which is a key process in the pathogenesis of emphysema. The...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: King, Paul T., Sharma, Roleen, O’Sullivan, Kim M., Callaghan, Judy, Dousha, Lovisa, Thomas, Belinda, Ruwanpura, Saleela, Lim, Steven, Farmer, Michael W., Jennings, Barton R., Finsterbusch, Michaela, Brooks, Gavin, Selemidis, Stavros, Anderson, Gary P., Holdsworth, Stephen R., Bardin, Philip G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608940/
https://ncbi.nlm.nih.gov/pubmed/28935869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12474-5
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