Glycogen Synthase Kinase-3β Inhibition Links Mitochondrial Dysfunction, Extracellular Matrix Remodelling and Terminal Differentiation in Chondrocytes

Following inflammatory stimuli, GSK3 inhibition functions as a hub with pleiotropic effects leading to cartilage degradation. However, little is known about the effects triggered by its direct inhibition as well as the effects on mitochondrial pathology, that contributes to osteoarthritis pathogenes...

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Vydáno v:Sci Rep
Hlavní autoři: Guidotti, S., Minguzzi, M., Platano, D., Santi, S., Trisolino, G., Filardo, G., Mariani, E., Borzì, R. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608843/
https://ncbi.nlm.nih.gov/pubmed/28935982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12129-5
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