Rat precision-cut liver slices predict drug-induced cholestatic injury

Drug-induced cholestasis (DIC) is one of the leading manifestations of drug-induced liver injury (DILI). As the underlying mechanisms for DIC are not fully known and specific and predictive biomarkers and pre-clinical models are lacking, the occurrence of DIC is often only reported when the drug has...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Starokozhko, Viktoriia, Greupink, Rick, van de Broek, Petra, Soliman, Nashwa, Ghimire, Samiksha, de Graaf, Inge A. M., Groothuis, Geny M. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2017
Assuntos:
In Vitro Sysytems
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608839/
https://ncbi.nlm.nih.gov/pubmed/28391356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-017-1960-7
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