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Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach
Hepatotoxicity is one of the major reasons for withdrawal of drugs from the market. Therefore, there is a need to screen new drugs for hepatotoxicity in humans at an earlier stage. The aim of this study was to validate human precision-cut liver slices (PCLS) as an ex vivo model to predict drug-induc...
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| Publicado no: | Arch Toxicol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5316400/ https://ncbi.nlm.nih.gov/pubmed/27344345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1778-8 |
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