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Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition

PURPOSE: Small-molecule inhibitors of heat-shock protein 90 (HSP90) have been under development as chemotherapeutic agents. The adverse events reported from early clinical trials included hyponatremia. Given the limited number of patients enrolled, the number of hyponatremia incidents was remarkable...

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Publicat a:Cancer Chemother Pharmacol
Autors principals: Yang, Qiong, Puhm, Florian, Freissmuth, Michael, Nanoff, Christian
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608778/
https://ncbi.nlm.nih.gov/pubmed/28779264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3390-x
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