HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes

T-cell-based immunotherapies are promising treatments for cancer patients. Although durable responses can be achieved in some patients, many patients fail to respond to these therapies, underscoring the need for improvement with combination therapies. From a screen of 850 bioactive compounds, we ide...

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Publicado no:Nat Commun
Main Authors: Mbofung, Rina M., McKenzie, Jodi A., Malu, Shruti, Zhang, Min, Peng, Weiyi, Liu, Chengwen, Kuiatse, Isere, Tieu, Trang, Williams, Leila, Devi, Seram, Ashkin, Emily, Xu, Chunyu, Huang, Lu, Zhang, Minying, Talukder, Amjad H., Tripathi, Satyendra C., Khong, Hiep, Satani, Nikunj, Muller, Florian L., Roszik, Jason, Heffernan, Timothy, Allison, James P., Lizee, Gregory, Hanash, Sam M., Proia, David, Amaria, Rodabe, Davis, R. Eric, Hwu, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587668/
https://ncbi.nlm.nih.gov/pubmed/28878208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00449-z
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