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Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition

PURPOSE: Small-molecule inhibitors of heat-shock protein 90 (HSP90) have been under development as chemotherapeutic agents. The adverse events reported from early clinical trials included hyponatremia. Given the limited number of patients enrolled, the number of hyponatremia incidents was remarkable...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Yang, Qiong, Puhm, Florian, Freissmuth, Michael, Nanoff, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608778/
https://ncbi.nlm.nih.gov/pubmed/28779264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3390-x
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